CAD Tools for Synthetic Biology
Under construction ...
Presentation
Tutorial
A video tutorial of the automated model generator which was record for iGEM 2011 is available on Youtube and is insert below. Only minor graphical modifications on the interface were done since this video.
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Downloads
Automated model generator
You can download the software at this link :File:Model_Generatorv0.1.zip.
Compatibility : Windows XP or superior.
After entering the system, this software generates different models files. However, to simulate the system, Dolphin SMASH is requiered.
Models files of three biosystems
microRNAs detector
The model files for the biosystem from Xie et al. can be download at this link: File:miR Detector.zip
Reference: Z. Xie, L. Wroblewska, L. Prochazka, R. Weiss, and Y. Benenson, “Multi-Input RNAi-Based Logic Circuit for Identification of Specific Cancer Cells,” Science, vol. 333, pp. 1307-1311, 2011.
Biological half-adder
The model files for the biosystem from Ausländer et al. can be download at this link: File:Half-adder.zip
Reference: S. Ausländer, D. Ausländer, M. Müller, M. Wieland, and M. Fussenegger, “Programmable single-cell mammalian biocomputers.,” Nature, vol. 487, no. 7405, pp. 123–7, Jul. 2012.
Biological oscillator
The model files for the biosystem from Stricker et al. can be download at this link: File:Oscillator.zip
Reference: J. Stricker, S. Cookson, M. R. Bennett, W. H. Mather, L. S. Tsimring, and J. Hasty, “A fast, robust and tunable synthetic gene oscillator.,” Nature, vol. 456, no. 7221, pp. 516–9, Nov. 2008.